Laboratory for Sensory Circuit Formation
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Original Papers

Distorted coarse axon targeting and reduced dendrite connectivity underlie dysosmia after olfactory axon injury.
Murai A, Iwata R, Fujimoto S, Aihara S, Tsuboi A, Muroyama Y, Saito T, Nishizaki K, Imai T.
eNeuro 2016;3(5):e0242-16.2016 doi:10.1523/ENEURO.0242-16.2016 [PubMed] [PDF] [NeuroMorph.org] [CDBニュース]

Super-resolution mapping of neuronal circuitry with an index optimized clearing agent.
Ke M-T, Nakai Y, Fujimoto S, Takayama R, Yoshida S, Kitajima TS, Sato M, Imai T.
Cell Reports 2016 March 22;14:2718-2732. doi:10.1016/j.celrep.2016.02.057 [PubMed] [PDF] [SeeDB Resources] [SeeDB2 Videos] [NeuroMorph.org]
[プレスリリース(理研)] [プレスリリース(JST)] [press release(RIKEN)] [CDBニュース] [YouTube(1)] [YouTube(2)] [YouTube(3)]

Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons.
Nakashima A*, Takeuchi H*, Imai T*, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Ron Yu C, Storm DR, Nishizumi H, Sakano H. (*equally contributed)
Cell. 2013 Sept 12;154:1314-1325. doi:10.1016/j.cell.2013.08.033 [PubMed] [Cell preview][F1000] [CDBニュース]

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction
Ke M-T, Fujimoto S, Imai T.
Nat Neurosci. 2013 June 23;16:1154-1161. doi:10.1038/nn.3447 [PubMed] [PDF] [Suppl] [SeeDB Resources] [SeeDB Videos][F1000] [NeuroMorph.org]
[プレスリリース(理研)] [プレスリリース(JST)] [press release(RIKEN)] [RIKEN RESEARCH] [CDBニュース] [YouTube(1)] [YouTube(2)] [YouTube(3)] [ScienceNOW] [サイエンスチャンネル(YouTube)]

A major allogenic leukocyte antigen in the agnathan hagfish.
Takaba H, Imai T, Miki S, Morishita Y, Miyashita A, Ishikawa N, Nishizumi H, Sakano H.
Sci Rep. 2013 Apr 24;3:1716. doi: 10.1038/srep01716. [PubMed]

Quartz-Seq: a highly reproducible and sensitive single-cell RNA-Seq reveals non-genetic gene expression heterogeneity.
Sasagawa Y, Nikaido I, Hayashi T, Danno H, Uno KD, Imai T, Ueda HR.
Genome Biol. 2013 Apr 17;14(4):R31. [PubMed]

Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes respond differently to phenyl ethers.
Tsuboi A*, Imai T*, Kato HK, Matsumoto H, Igarashi KM, Suzuki M, Mori K, Sakano H. (*equally contributed)
Eur J Neurosci. 2011 Jan;33(2):205-13. doi: 10.1111/j.1460-9568.2010.07495.x. [PubMed] [PDF]

Pre-Target Axon Sorting Establishes the Neural Map Topography.
Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H.
Science. 2009 Jul 31;325(5940):585-560. [PubMed] [PDF] [Suppl]
[Science preview] [Nature Review Neurosci Highlight] [F1000] [プレスリリース] [理学部ニュースPDF]

RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule.
Nishihara T, Nagawa F, Imai T, Sakano H.
J Biol Chem. 2008 Feb 22;283(8):4877-85. [PubMed]

Innate versus learned odour processing in the mouse olfactory bulb.
Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikawa M, Okabe M, Ikeda T, Itohara S, Kikusui T, Mori K, Sakano H.
Nature. 2007 Nov 22;450(7169):503-8. [PubMed] [プレスリリース]

Odorant receptor-derived cAMP signals direct axonal targeting.
Imai T, Suzuki M, Sakano H.
Science. 2006 Oct 27;314(5799):657-61. [PubMed] [PDF] [Suppl]
[Science preview] [Cell preview] [F1000] [プレスリリース][理学部ニュースPDF]

Olfactory sensory neurons expressing class I odorant receptors converge their axons on an antero-dorsal domain of the olfactory bulb in the mouse.
Tsuboi A, Miyazaki T, Imai T, Sakano H.
Eur J Neurosci. 2006 Mar;23(6):1436-44. [PubMed]

Developmental elimination of ectopic projection sites for the transgenic OR gene that has lost zone specificity in the olfactory epithelium.
Nakatani H, Serizawa S, Nakajima M, Imai T, Sakano H.
Eur J Neurosci. 2003 Nov;18(9):2425-32. [PubMed]

Reviews

組織透明化試薬を用いた3D蛍光イメージングのすすめ
今井 猛
生化学 2015 Apr;87(2):225-229. [生化学PDF]

組織透明化試薬を用いた生体試料の深部イメージング技術
今井 猛
光学 2014 Nov;43(11):524-526. [PDF] [光学]

Construction of functional neuronal circuitry in the olfactory bulb.
Imai T
Seminars in Cell & Developmental Biology 2014 July 30;35:180-188.
[PubMed] [PDF]

Optical clearing of fixed brain samples using SeeDB.
Ke M-T, Imai T
Current Protocols in Neuroscience 2014, Jan;66:2.22.1-19.
doi: 10.1002/0471142301.ns0222s66 [PDF]

組織透明化試薬SeeDBを用いた脳の3D蛍光イメージング
柯 孟岑 、今井 猛
実験医学 2014 Feb;32(3):449-455. [PDF] [実験医学]

Positional information in neural map development: Lessons from the olfactory system.
Imai T
Dev Growth Differ. 2012 Apr;54(3):358-65. doi: 10.1111/j.1440-169X.2012.01334.x. [PubMed] [PDF]

Axon-axon interactions in neuronal circuit assembly: lessons from olfactory map formation.
Imai T, & Sakano H
Eur J Neurosci. 2011 Nov; 34(10):1647-1654. [PubMed] [PDF]

Topographic Mapping--The Olfactory System.
Imai T, Sakano H, & Vosshall LB,
Cold Spring Harb Perspect Biol. (Neuronal Guidance; Marc Tessier-Lavigne and Alex L. Kolodkin ed.; CSHL press) 2010 Aug 1;2(8):a001776. [journal home] [PDF(preprint)]

軸索間相互作用に基づく神経地図形成のロジック
今井 猛, 山ア 崇裕, 坂野 仁
細胞工学 2010 Jan;29(1):78-85. [PDF]

軸索間相互作用による神経地図形成
今井 猛, 山ア 崇裕, 坂野 仁
実験医学 2009 Dec;27(19):3123-3126. [実験医学]

Odorant receptor gene choice and axonal projection in the mouse olfactory system.
Imai T, Sakano H.
Results Probl Cell Differ. (Chemosensory Systems in Mammals, Fishes, and Insects; Wolfgang Meyerhof and Sigrun Korsching ed.; Springer) 2009;47:1-19. [PubMed]

Odorant receptor-mediated signaling in the mouse.
Imai T, Sakano H.
Curr Opin Neurobiol. 2008 Jun;18(3):251-60.[PubMed] [PDF]

Interhemispheric olfactory circuit and the memory beyond.
Imai T, Sakano H.
Neuron. 2008 May 22;58(4):465-7. [PubMed][PDF]

嗅覚受容体に依存した軸索投射の分子機構 [Molecular mechanisms of odorant receptor-instructed axonal projection]
Imai T, Sakano H.
生化学 [Seikagaku]. 2007 Dec;79(12):1148-52. Japanese [PubMed][PDF]

Axonal Wiring Specificity by Differential cAMP Levels in the Mouse Olfactory System (GE & Science Prize winning essay).
Imai T
Science (online). 2007 Dec. [Science online]

Roles of odorant receptors in projecting axons in the mouse olfactory system.
Imai T, Sakano H.
Curr Opin Neurobiol. 2007 Oct;17(5):507-15. [PubMed] [PDF]


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